Induction of Ovulation in the Human with Human Gonadotropins *

INDUCTION OF OVULATION IN THE HUMAN WITH HUMAN GONADOTROPINS.* By C. Lee Buxton and Walter Herrmann, Department of Obstetrics and Gynecology, Yale University School of Medicine. During the 33 years since human chorionic gonadotropin (hereafter to be designated as HCG) was shown to produce ovulation in small mammals, there have been numerous unsatisfactory attempts to stimulate human ovarian activity by various gonadotropin extracts.2 Recent evidence of successful species specific gonadotropin extract administration in the monkey and human has been presented by van Wagenen and Simpson8 and by Gemzell.' The extract used by injection in the present series (HPG) ** was obtained from human autopsy material, regardless of the age or sex of the subject. This was prepared by extracting the lyophilized pituitary glands